Fourth Starr Cancer Consortium Grant Competition

(in alphabetical order by principal investigator)

Competing Project Renewal Awards

  • "Breast Cancer Protective Alleles by Whole Genome Association and Copy Number"

    Principal Investigator:

    • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center<.li>

    Co-Principal Investigator:

    • David Altshuler, MD, PhD, The Broad Institute of MIT & Harvard
  • "Role of Alternative Splicing in the Regulation of Cancer-Cell Metabolism"

    Principal Investigator:

    • Adrian Krainer, PhD, Cold Spring Harbor Laboratory

    Co-Principal Investigators:

    • Lewis Cantley, PhD, The Broad Institute of MIT & Harvard
    • Matthew Vander Heiden, MD, PhD, The Broad Institute of MIT & Harvard

New Awards

  • "EphA Receptor Signaling - A New, Soluble Tumor Suppressor Pathway in Lymphoma"

    Principal Investigator:

    • Hans-Guido Wendel, MD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Juha-P Himanen, PhD, Memorial Sloan-Kettering Cancer Center
    • Brain Chait, DPhil, The Rockefeller University
  • "Development of Quantitative Proteomic and Transcriptomic Approaches to Decipher Posttranscriptional Regulation in Cancer Pathogenesis "

    Principal Investigator:

    • Thomas Tuschl, PhD, The Rockefeller University

    Co-Principal Investigators:

    • Christine Mayr, MD, PhD, Memorial Sloan-Kettering Cancer Center
    • Christina Leslie, PhD, Memorial Sloan-Kettering Cancer Center
    • Shao-En Ong, PhD, The Broad Institute of MIT & Harvard
  • "Functional Genetic and Proteomic Analysis of Sensitivity and Resistance to Targeted Therapies"

    Principal Investigator:

    • Kimberly Stegmaier, MD, The Broad Institute of MIT & Harvard

    Co-Principal Investigators:

    • Ross Levine, MD, Memorial Sloan-Kettering Cancer Center
    • Benjamin Ebert, MD, PhD, The Broad Institute of MIT & Harvard
  • "Functional Characterization of Genomic Abnormalities that Cooperate with EGFR and K-RAS Oncogenic Mutations in Lung Tumorigenesis"

    Principal Investigator:

    • Raffaella Sordella, PhD, Cold Spring Harbor Laboratory

    Co-Principal Investigators:

    • Linda Van Aelst, PhD, Cold Spring Harbor Laboratory
    • Scott Lowe, PhD, Cold Spring Harbor Laboratory
    • Vivek Mittal, PhD, Weill Cornell Medical College
    • Chris Sander, PhD, Memorial Sloan-Kettering Cancer Center
    • Marc Ladanyi, MD, Memorial Sloan-Kettering Cancer Center
  • "Identification and Functional Analysis of Novel Cancer Susceptibility Genes in Fanconi Anemia and Familial Breast Cancer Patients"

    Principal Investigator:

    • Agata Smogorzewska, MD, PhD, The Rockefeller University

    Co-Principal Investigators:

    • Stacey Gabriel, PhD, The Broad Institute of MIT & Harvard
    • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center
  • "Elucidating Mechanisms of ETS-mediated Oncogenesis in Prostate Cancer and Gastrointestinal Stromal Tumor (GIST)"

    Principal Investigator:

    • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center 

    Co-Principal Investigator:

    • C. David Allis, PhD, The Rockefeller University
  • "Functional Validation of Somatic Mutations in Prostate Cancer"

    Principal Investigator:

    • Mark Rubin, MD, Weill Cornell Medical College

    Co-Principal Investigators:

    • Levi Garraway, MD, PhD, The Broad Institute of MIT & Harvard
    • Ashutosh Tewari, MD, MCh, Weill Cornell Medical College
    • Gad Getz, PhD, The Broad Institute of MIT & Harvard
    • Francesca Demichelis, PhD, Weill Cornell Medical College
  • "Development of Mechanism-Based Therapies for the Treatment of Metastatic Melanoma"

    Principal Investigator:

    • Neal Rosen, MD, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Levi Garraway, MD, PhD, The Broad Institute of MIT & Harvard
    •  William Hahn, MD, PhD, The Broad Institute of MIT & Harvard
    • David Solit, MD, Memorial Sloan-Kettering Cancer Center
    • Jedd Wolchok, MD, PhD, Memorial Sloan-Kettering Cancer Center
    • Alan Houghton, MD, Memorial Sloan-Kettering Cancer Center
    • Paul Chapman, MD, Memorial Sloan-Kettering Cancer Center
    • Gary Schwartz, MD, Memorial Sloan-Kettering Cancer Center
    • Lynda Chin, MD, The Broad Institute of MIT & Harvard
  • "Epigenetic Mechanisms of the Mixed Lineage Leukemia 1 (MLL1) Protein in Human Leukemogenesis Mediated by Specific Interactions with the PAF Transcription Elongation Complex"

    Principal Investigator:

    • Robert Roeder, PhD, The Rockefeller University

    Co-Principal Investigators:

    • C. David Allis, PhD, The Rockefeller University
    • Scott Lowe, PhD, The Cold Spring Harbor Laboratory
    • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center
  • "Mechanisms Determining Disease Relapse in Older Patients with Acute Myeloid Leukemia"

    Principal Investigator:

    • Ari Melnick, MD, Weill Cornell Medical College

    Co-Principal Investigators:

    • Ross Levine, MD, Memorial Sloan-Kettering Cancer Center
    • Gail Roboz, MD. Weill Cornell Medical College
    • Monica Guzman, PhD, Weill Cornell Medical College
    • Christopher Park, MD, PhD, Memorial Sloan-Kettering Cancer Center
    • Christopher Mason, PhD, Weill Cornell Medical College
  • "Chemical Biology Approaches to Dissect Protein Methylation in Hematopoietic Cancer"

    Principal Investigator:

    • Minkui Luo, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Haiteng Deng, PhD, The Rockefeller University
    • Stephen Nimer, MD, Memorial Sloan-Kettering Cancer Center
  • "Integrative Computational Analysis to Drive Discovery of microRNA-mediated Regulatory Networks in Cancer"

    Principal Investigator:

    • Christina Leslie, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigator:

    • Olivier Elemento, PhD, Weill Cornell Medical College
    • Christopher Mason, Weill Cornell Medical College
    • Eric Holland, MD, PhD, Memorial Sloan-Kettering Cancer Center
    • Chris Sander, PhD, Memorial Sloan-Kettering Cancer Center
  • "Molecular Imaging to Assess Tumor-associated Macrophages with Targeted Nanoparticles"

    Principal Investigator:

    • Jan Grimm, MD, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Jason Lewis, PhD, Memorial Sloan-Kettering Cancer Center
    • Ralph Weissleder, MD, PhD, The Broad Institute of MIT & Harvard
  • "Ago-miRNA Dysregulation in Primary and Metastatic Breast Cancer"

    Principal Investigator:

    • Robert Darnell, MD, PhD, The Rockefeller University

    Co-Principal Investigator:

    • Joan Massagué, PhD, Memorial Sloan-Kettering Cancer Center
  • "AID: Roles in Oncogenesis and Tumor Relapse"

    Principal Investigator:

    • Jayanta Chaudhuri, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Nina Papavasiliou, PhD, The Rockefeller University
    • Hans-Guido Wendel, MD, Memorial Sloan-Kettering Cancer Center
  • "Unraveling the Breast Cancer Metastasis Epigenome"

    Principal Investigator:

    • Timothy Chan, MD, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Linda Vahdat, MD, Weill Cornell Medical College
    • Sohail Tavazoie, MD, PhD, The Rockefeller University