Third Starr Cancer Consortium Grant Competition

Competing Project Renewal Awards

  • "Mis-regulation of Protein Translation in the Pathogenesis and Treatment of Cancer"

    Principal Investigator:

    • Michael B. Yaffe, PhD, Broad Institute of MIT and Harvard

    Co-Principal Investigators:

    • Steven Carr, PhD, Broad Institute of MIT and Harvard
    • Andrew Koff, PhD, Memorial Sloan-Kettering Cancer Center
  • "Comparative Oncogenomics to Discover Oncogene Synthetic Lethality"

    Principal Investigator:

    • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard

    Co-Principal Investigators:

    • Greg Hannon, PhD, Cold Spring Harbor Laboratory
    • Scott Lowe, PhD, Cold Spring Harbor Laboratory

New Awards

  • "Structural and Functional Definition of Posttranscriptional Regulatory Networks of Tumor-associated RNA-binding Proteins"

    Principal Investigator:

    • Thomas Tuschl, PhD, The Rockefeller University

    Co-Principal Investigators:

    • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center
    • Samuel Singer, MD, Memorial Sloan-Kettering Cancer Center
  • "The Role of PHLPP Phosphatases in PTEN-Mutant Prostate Cancer Progression"

    Principal Investigator:

    • Lloyd C. Trotman, PhD, Cold Spring Harbor Laboratory

    Co-Principal Investigators:

    • Brett Carver, MD, Memorial Sloan-Kettering Cancer Center
    • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center

  • "Identification of microRNAs that Predict Metastatic Relapse and Sensitivity to Chemotherapy in Human Colorectal Cancer"

    Principal Investigator:

    • Sohail Tavazoie, MD, PhD, The Rockefeller University

    Co-Principal Investigators:

    • Timothy Chan, MD, PhD, Memorial Sloan-Kettering Cancer Center
    • Dilip Giri, MD, Memorial Sloan-Kettering Cancer Center
    • Philip Paty, MD, Memorial Sloan-Kettering Cancer Center
    • Leonard Saltz, MD, Memorial Sloan-Kettering Cancer Center
  • "Control of Prostate Cancer Progression by Ezh2-mediated Cytosolic Protein Lysine Methylation"

    Principal Investigator:

    • Alexander Tarakhovsky, MD, PhD, The Rockefeller University

    Co-Principal Investigator:

    • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center
  • "An Integrative Paradigm for the Discovery of Novel Tumor Subtypes and Associated Cancer Genes"

    Principal Investigator:

    • Ronglai Shen, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Douglas Levine, MD, Memorial Sloan-Kettering Cancer Center
    • Scott Powers, PhD, Cold Spring Harbor Laboratory
  • "Genomic Analysis of Circulating Tumor Cells to Evaluate Predictive Biomarkers"

    Principal Investigator:

    • Howard Scher, MD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigator:

    • Daniel Haber, MD, PhD, The Broad Institute of MIT and Harvard
    • W. Richard McCombie, PhD, Cold Spring Harbor Laboratory
    • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center
  • "Genomic Structural Variation in Cancer Susceptibility"

    Principal Investigator:

    • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigator:

    • Larry Norton, MD, Memorial Sloan-Kettering Cancer Center
    • Michael Wigler, PhD,  Cold Spring Harbor Laboratory
  • "Genomic Damage by Activation Induced Deaminase"

    Principal Investigator:

    • Michel Nussenzweig, MD, PhD, The Rockefeller University

    Co-Principal Investigator:

    • David Root, PhD, The Broad Institute of MIT and Harvard
  • "Pathogen Discovery in AIDS-related Lymphoma by Next-generation Sequencing"

    Principal Investigator:

    • Matthew Meyerson, MD, PhD, The Broad Institute of MIT and Harvard

    Co-Principal Investigator:

    • Ethel Ceserman, MD, PhD, Weill Cornell Medical College
  • "Integrated Genetic Analysis of Epithelial Ovarian Cancer"

    Principal Investigator:

    • Robert Lucito, PhD, Cold Spring Harbor Laboratory

    Co-Principal Investigators:

    • Douglas Levine, MD, Memorial Sloan-Kettering Cancer Center
    • Li-Xuan Qin, PhD, Memorial Sloan-Kettering Cancer Center
    • Nicholas Tonks, PhD, Cold Spring Harbor Laboratory
  • "Genome Wide Mapping of FoxO1 Binding-sites in vivo and Functional Study of FoxO1 Target Genes in Mouse T Lymphocytes"

    Principal Investigator:

    • Ming Li, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigator:

    • Michael Zhang, PhD, Cold Spring Harbor Laboratory
  • "ZIRCONIUM-89 (ZR-89) J591 based Positron Emission Tomography (ImmunoPET) as a Basis for Improving Diagnostic Imaging of Prostate Cancer"

    Principal Investigator:

    • Steven M. Larson, MD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Neil Bander, MD, Weill Cornell Medical College
    • Jorge Carrasquillo, MD, Memorial Sloan-Kettering Cancer Center
    • Mithat Gonen, PhD, Memorial Sloan-Kettering Cancer Center
    • Jason Lewis, PhD, Memorial Sloan-Kettering Cancer Center
    • Massimo Loda, MD, The Broad Institute of MIT and Harvard
    • Michael Morris, MD, Memorial Sloan-Kettering Cancer Center
    • Neeta Pandit-Taskar, MD, Memorial Sloan-Kettering Cancer Center
  • "Elucidation of microRNA Control of Cell Signaling and Apoptosis Pathways"

    Principal Investigator:

    • Eric Lai, PhD, Memorial Sloan-Kettering Cancer Center

    Co-Principal Investigators:

    • Xuejun Jiang, PhD, Memorial Sloan-Kettering Cancer Center
    • Yuri Lazebnik, PhD, Cold Spring Harbor Laboratory
    • Norbert Perrimon, PhD, The Broad Institute of MIT and Harvard
  • "Functional Analysis of Cell-Specific Pharmacology on Tumor Microenvironments"

    Principal Investigator:

    • Howard Hang, PhD, The Rockefeller University

    Co-Principal Investigator:

    • Mikala Egeblad, PhD, Cold Spring Harbor Laboratory
  • "Sensitizing shRNA Screen for Molecular Targets in CDK4/CDK6-Based Cancer Therapy"

    Principal Investigator:

    • Selina Chen-Kiang, PhD, Weill Cornell Medical College

    Co-Principal Investigators:

    • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard
    • Pengbo Zhou, PhD, Weill Cornell Medical College