2010 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.

Park JH, Sun XJ, Roeder RG.

Molecular and Cellular Biology
Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.

Yu EY, Yen WF, Steinberg-Neifach O, Lue NF.

Molecular and Cellular Biology
Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and Is More Effective When Combined with Dasatinib.

Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P.

Molecular Cancer Research
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.

Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL.

Nature
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.

Nature
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N.

Nature
TRIM24 links a non-canonical histone signature to breast cancer.

Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC.

Nature
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

Chatterjee C, McGinty RK, Fierz B, Muir TW.

Nature Chemical Biology
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S.

Nature Genetics
Foxo proteins cooperatively control the differentiation of Foxp3(+) regulatory T cells.

Ouyang W, Beckett O, Ma Q, Paik JH, Depinho RA, Li MO.

Nature Immunology
Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors.

Adli M, Zhu J, Bernstein BE.

Nature Methods
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.

Chi P, Allis CD, Wang GG.

Nature Reviews, Cancer
Optimizing copy number variation analysis using genome-wide short sequence oligonucleotide arrays.

Oldridge DA, Banerjee S, Setlur SR, Sboner A, Demichelis F.

Nucleic Acids Research
Genetic determinants at the interface of cancer and neurodegenerative disease.

Morris, LGT; Veeriah, S; Chan, TA.

Oncogene
Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer.

Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, et al.

PLoS Genetics
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR.

Proceedings of the National Academy of Sciences of the USA
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.

Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N.

Proceedings of the National Academy of Sciences of the USA
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3 ' UTRs.

Schnall-Levin, M; Zhao, Y; Perrimon, N; Berger, B.

Proceedings of the National Academy of Sciences of the USA
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.

Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC.

Proceedings of the National Academy of Sciences of the USA
Plasticity of telomere maintenance mechanisms in yeast.

Lue NF.

Trends in Biochemical Sciences

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