2011 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

Biswas, D; Milne, TA; Basrur, V; Kim, J; Elenitoba-Johnson, KSJ; Allis, CD; Roeder, RG.

Proceedings of the National Academy of Sciences of the USA
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.

Morris LG, Taylor BS, Bivona TG, Gong Y, Eng S, Brennan CW, Kaufman A, Kastenhuber ER, Banuchi VE, Singh B, Heguy A, Viale A, Mellinghoff IK, Huse J, Ganly I, Chan TA.

Proceedings of the National Academy of Sciences of the USA
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries.

Hafner, M; Renwick, N; Brown, M; Mihailovic, A; Holoch, D; Lin, C; Pena, JTG; Nusbaum, JD; Morozov, P; Ludwig, J; Ojo, T; Luo, SJ; Schroth, G; Tuschl, T.

RNA
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs.

Smibert P, Bejarano F, Wang D, Garaulet DL, Yang JS, Martin R, Bortolamiol-Becet D, Robine N, Hiesinger PR, Lai EC.

RNA
Widespread regulatory activity of vertebrate microRNA* species.

Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC.

RNA
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC.

Science
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma.

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence M, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio R, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR.

Science
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.

Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD.

Science
Breast cancer methylomes establish an epigenomic foundation for metastasis.

Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA.

Science Translational Medicine
miRNAs in human cancer.

Farazi TA, Spitzer JI, Morozov P, Tuschl T.

The Journal of Pathology
Foxo: in command of T lymphocyte homeostasis and tolerance.

Ouyang, WM; Li, MO.

Trends in Immunology
Development and cancer of the cerebellum.

Hatten ME, Roussel MF.

Trends in Neurosciences

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