2013 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction.

Wilkinson AC, Ballabio E, Geng H, North P, Tapia M, Kerry J, Biswas D, Roeder RG, Allis CD, Melnick A, de Bruijn MF, Milne TA.

Cell Reports
Phase II trial of MEK inhibitor selumetinib (AZD6244) in patients with BRAFV600E/K-mutated melanoma.

Catalanotti F, Solit DB, Pulitzer MP, Berger M, Scott SN, Iyriboz T, Lacouture ME, Panageas K, Wolchok JD, Carvajal RD, Schwartz GK, Rosen N, Chapman PB.

Clinical Cancer Research
A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells.

Wang R, Luo M.

Current Opinion in Chemical Biology
Profiling protein methylation with cofactor analog containing terminal alkyne functionality.

Blum G, Bothwell IR, Islam K, Luo M.

Current Protocols in Chemical Biology
Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine.

Blum G, Islam K, Luo M.

Current Protocols in Chemical Biology
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.

Dai Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH, Lai EC.

Development
A TAF4 coactivator function for E proteins that involves enhanced TFIID binding.

Chen WY, Zhang J, Geng H, Du Z, Nakadai T, Roeder RG.

Genes & Development
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression.

Lianoglou S, Garg V, Yang JL, Leslie CS, Mayr C.

Genes & Development
Induction of sarcomas by mutant IDH2.

Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB.

Genes & Development
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, Muhar M, Haslinger C, Yu M, Roeder RG, Wigler MA, Blobel GA, Zuber J, Spector DL, Young RA, Vakoc CR.

Genes & Development
Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.

Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ.

Genes & Development
Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies.

Goddard KA, Whitlock EP, Berg JS, Williams MS, Webber EM, Webster JA, Lin JS, Schrader KA, Campos-Outcalt D, Offit K, Feigelson HS, Hollombe C.

Genetics in Medicine
Inferring chromatin-bound protein complexes from genome-wide binding assays.

Giannopoulou EG, Elemento O.

Genome Research
Widespread and extensive lengthening of 3' UTRs in the mammalian brain.

Miura P, Shenker S, Andreu-Agullo C, Westholm JO, Lai EC.

Genome Research
Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis.

Lum E, Vigliotti M, Banerjee N, Cutter N, Wrzeszczynski KO, Khan S, Kamalakaran S, Levine DA, Dimitrova N, Lucito R.

Gynecologic Oncology
The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.

Kim MV, Ouyang W, Liao W, Zhang MQ, Li MO.

Immunity
Multicolor microRNA FISH effectively differentiates tumor types.

Renwick N, Cekan P, Masry PA, McGeary SE, Miller JB, Hafner M, Li Z, Mihailovic A, Morozov P, Brown M, Gogakos T, Mobin MB, Snorrason EL, Feilotter HE, Zhang X, Perlis CS, Wu H, Suárez-Fariñas M, Feng H, Shuda M, Moore PS, Tron VA, Chang Y, Tuschl T.

Journal of Clinical Investigation
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.

Kwan WH, van der Touw W, Paz-Artal E, Li MO, Heeger PS.

Journal of Experimental Medicine
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, Pandey S, Shin JY, Telis L, Liu J, Bhatt PK, Monette S, Zhao X, Mason CE, Park CY, Bernstein BE, Aifantis I, Levine RL.

Journal of Experimental Medicine
Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells.

Wang R, Islam K, Liu Y, Zheng W, Tang H, Lailler N, Blum G, Deng H, Luo M.

Journal of the American Chemical Society

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