2015 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD.

Nature
A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.

Fulga, TA; McNeill, EM; Binari, R; Yelick, J; Blanche, A; Booker, M; Steinkraus, BR; Schnall-Levin, M; Zhao, Y; DeLuca, T; Bejarano, F; Han, Z; Lai, EC; Wall, DP; Perrimon, N; Van Vactor, D

Nature Communications
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity.

Moore MJ, Scheel TK, Luna JM, Park CY, Fak JJ, Nishiuchi E, Rice CM, Darnell RB.

Nature Communications
Epigenomic evolution in diffuse large B-cell lymphomas.

Pan H, Jiang Y, Boi M, Tabbò F, Redmond D, Nie K, Ladetto M, Chiappella A, Cerchietti L, Shaknovich R, Melnick AM, Inghirami GG, Tam W, Elemento O.

Nature Communications
An allelic series of miR-17∼92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.

Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A.

Nature Genetics
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW.

Nature Genetics
Interactive analysis and assessment of single-cell copy-number variations.

Garvin T, Aboukhalil R, Kendall J, Baslan T, Atwal GS, Hicks J, Wigler M, Schatz MC.

Nature Methods
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

Huang H, Strømme CB, Saredi G, Hödl M, Strandsby A, González-Aguilera C, Chen S, Groth A, Patel DJ.

Nature Structural and Molecular Biology
Signatures of accelerated somatic evolution in gene promoters in multiple cancer types.

Smith KS, Yadav VK, Pedersen BS, Shaknovich R, Geraci MW, Pollard KS, De S.

Nucleic Acids Research
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers.

Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay GR, Librado P, et al.

PLoS One
A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.

Santiago-Tirado FH, Peng T, Yang M, Hang HC, Doering TL.

PLoS Pathogens
Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

Dequéant ML, Fagegaltier D, Hu Y, Spirohn K, Simcox A, Hannon GJ, Perrimon N.

Proceedings of the National Academy of Sciences of the USA
Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, Lee W, Yuan J, Wong P, Ho TS, Miller ML, Rekhtman N, Moreira AL, Ibrahim F, Bruggeman C, Gasmi B, Zappasodi R, Maeda Y, Sander C, Garon EB, Merghoub T, Wolchok JD, Schumacher TN, Chan TA.

Science
Identification of an oncogenic RAB protein.

Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.

Science
Embryonic stem cell miRNAs and their roles in development and disease.

Vidigal JA, Ventura A.

Seminars in Cancer Biology
The biological functions of miRNAs: lessons from in vivo studies.

Vidigal JA, Ventura A.

Trends in Cell Biology

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