2021 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors.

Nguyen LH, Cao Y, Hur J, Mehta RS, Sikavi DR, Wang Y, Ma W, Wu K, Song M, Giovannucci EL, Rimm EB, Willett WC, Garrett WS, Izard J, Huttenhower C, Chan AT

Gastroenterology
Dietary interventions as regulators of stem cell behavior in homeostasis and disease.

Novak JSS, Baksh SC, Fuchs E

Genes & Development
Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men.

Ma W, Nguyen LH, Song M, Wang DD, Franzosa EA, et al.

Genome Medicine
Pilot Study of Dacomitinib for Patients With Metastatic EGFR-Mutant Lung Cancers With Disease Progression After Initial Treatment With Osimertinib.

Choudhury NJ, Makhnin A, Tobi YY, Daly RM, Preeshagul IR, Iqbal AN, Ahn LS, Hayes SA, Heller G, Kris MG, Riely GJ, Yu HA

JCO Precision Oncology
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.

Ceraudo E, Horioka M, Mattheisen JM, Hitchman TD, Moore AR, Kazmi MA, Chi P, Chen Y, Sakmar TP, Huber T

Journal of Biological Chemistry
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.

Pae J, Ersching J, Castro TBR, Schips M, Mesin L, et al.

Journal of Experimental Medicine
Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics.

Cifani P, Li Z, Luo D, Grivainis M, Intlekofer AM, et al.

Journal of Proteome Research
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.

Cho S, Lee G, Pickering BF, Jang C, Park JH, et al.

Molecular Cell
ER-directed TREX1 limits cGAS activation at micronuclei.

Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, et al.

Molecular Cell
H1 histones control the epigenetic landscape by local chromatin compaction.

Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, Yusufova N, Meydan C, Osunsade A, David Y, Cesarman E, Melnick AM, Sidoli S, Garcia BA, Edelmann W, Macian F, Skoultchi AI

Nature
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, Kelleher NL, Staudt LM, Skoultchi AI, Keogh MC, Apostolou E, Mason CE, Imielinski M, Schlick T, David Y, Tsirigos A, Allis CD, Soshnev AA, Cesarman E, Melnick AM

Nature
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

Garcia-Silva, S, Benito-Martin, A, Nogues, L, Hernandez-Barranco, A, Mazariegos, MS., et al.

Nature Cancer
Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, et al.

Nature Cancer
Harnessing nanotechnology to expand the toolbox of chemical biology.

Williams RM, Chen S, Langenbacher RE, Galassi TV, Harvey JD, et al.

Nature Chemical Biology
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis.

Gao T, Ptashkin R, Bolton KL, Fong C, Spitzer B, et al.

Nature Communications
Clonal hematopoiesis is associated with risk of severe Covid-19.

Bolton KL, Koh Y, Foote MB, Im H, Jee J, Sun CH, Safonov A, Ptashkin R, Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M, Derkach A, Gedvilaite E, Tkachuk KA, Wiley BJ, Chan IC, Braunstein LZ, Gao T, Papaemmanuil E, Esther Babady N, Pessin MS, Kamboj M, Diaz LA Jr, Ladanyi M, Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V, Offit K, Norton L, Berger MF, Levine RL, Kim ES, Kim NJ, Zehir A

Nature Communications
Structural variant evolution after telomere crisis.

Dewhurst SM, Yao X, Rosiene J, Tian H, Behr J, Bosco N, Takai KK, de Lange T, Imieliński M

Nature Communications
Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface.

Hunter MV, Moncada R, Weiss JM, Yanai I, White RM

Nature Communications
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers.

Mao N, Zhang Z, Lee YS, Choi D, Rivera AA, Li D, Lee C, Haywood S, Chen X, Chang Q, Xu G, Chen HA, de Stanchina E, Sawyers C, Rosen N, Hsieh AC, Chen Y, Carver BS

Nature Communications
Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells.

Tian C, Huang Y, Clauser KR, Rickelt S, Lau AN, et al.

Nature Communications

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