2021 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors.

Valero C, Lee M, Hoen D, Weiss K, Kelly DW, et al.

Nature Communications
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.

Chaligne R, Gaiti F, Silverbush D, Schiffman JS, Weisman HR, Kluegel L, Gritsch S, Deochand SD, Gonzalez Castro LN, Richman AR, Klughammer J, Biancalani T, Muus C, Sheridan C, Alonso A, Izzo F, Park J, Rozenblatt-Rosen O, Regev A, Suvà ML, Landau DA

Nature Genetics
The association between tumor mutational burden and prognosis is dependent on treatment context.

Valero C, Lee M, Hoen D, Wang J, Nadeem Z, et al.

Nature Genetics
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.

Rivas MA, Meydan C, Chin CR, Challman MF, Kim D, et al.

Nature Immunology
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.

Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, et al.

Nature Medicine
The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk.

Wang DD, Nguyen LH, Li Y, Yan Y, Ma W, et al.

Nature Medicine
A chemical genetics approach to examine the functions of AAA proteins.

Cupido T, Jones NH, Grasso MJ, Pisa R, Kapoor TM

Nature Structural & Molecular Biology
Cooperative DNA looping by PRC2 complexes.

Lin X, Leicher R, Liu S, Zhang B

Nucleic Acids Research
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.

Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C

Pediatric Blood Cancer
Rapid interrogation of cancer cell of origin through CRISPR editing.

Feng W, Cao Z, Lim PX, Zhao H, Luo H, Mao N, Lee YS, Rivera AA, Choi D, Wu C, Han T, Romero R, de Stanchina E, Carver BS, Wang Q, Jasin M, Sawyers CL

Proceedings of the National Academy of Science of the United States of America
mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy.

Tang HW, Weng JH, Lee WX, Hu Y, Gu L, Cho S, Lee G, Binari R, Li C, Cheng ME, Kim AR, Xu J, Shen Z, Xu C, Asara JM, Blenis J, Perrimon N

Proceedings of the National Academy of Sciences
Developmental chromatin programs determine oncogenic competence in melanoma.

Baggiolini A, Callahan SJ, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L, White RM

Science
Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity.

Mendoza A, Yewdell WT, Hoyos B, Schizas M, Bou-Puerto R, Michaels AJ, Brown CC, Chaudhuri J, Rudensky AY

Science Immunology
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.

Baksh SC, Finley LWS

Trends in Cell Biology

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